GROTON BIOSYSTEMS ARS

KEY FEATURES and BENEFITS:
Sanitary Interface:..	The dual isolated remote valve interface provides complete isolation of the reactor from the ARS. This interface permits cleaning and flushing directly to the reactor port, protecting the reactor from contamination. CIP / SIP options available.
Automated Operation:..	The ARS features method development software to allow a sequence of operations lasting hours, days, and even weeks. This permits scheduled sampling of up to eight bioreactors 24 hours a day, 7 days a week. The ARS eliminates labor intensive, manual sampling processes.
Precision Sampling:..	The precision design of the ARS minimizes the amount of sample required from the reactor. The ARS pulls and delivers sample with outstanding consistency to ensure accurate assay results.
Sample Prep Options:..	In addition to pulling the sample, the ARS can prepare the sample for further processing or analysis. Sample Prep Options: cell lyzing (enzymatic or chemical); sample filtration; molecular weight separation in fractions; buffer exchange; sample dilution; and reagent addition.
On-Line Analysis and Sample Collection:..	The ARS can interface to nutrient monitors, HPLC systems, and cell counters as well as a fraction collector. When interfacing to analytical instruments the ARS delivers the sample to the instruments, triggers the analysis, and displays and logs the results. The ARS automatically cleans and prepares the transfer line for the next sample.
OPC Data Exchange:..	An optional OPC software package supports the collection of ARS status and process analytical data by a wide range of supervisory systems.
21 CFR Part 11 Compliance:..	An optional 21 CFR Part 11 software module is available.
Modular, Flexible Design:..	The ARS can acquire and deliver sample from input port (maximum of eight) to any output port (maximum of four). There is no manual configuration required. The design allows for maximum flexibility under software control.
Comprehensive System Support:..	The technical staffs at Groton Biosystems and RJM Sales have the experience and expertise to adapt the ARS to unique operating environments and procedures.

ON-LINE INSTRUMENT OPTIONS:
Fraction Collector:..	The ARS delivers samples to sterile vials in a fraction collector for post run analysis. Using Peltier temperature control, the fraction collector maintains temperature in a range of 4°C to 37°C. The standard rack supports 30 vials. Custom racks are available to meet individual requirements.
Nutrient Monitor:..	The ARS supports nutrient monitors from several vendors that can provide analysis for glucose, lactate, glutamate, glutamine, sucrose, ammonium, potassium, ethanol, lactate, methanol, and chlorine.
HPLC Systems:..	HPLC is one of the most widely used analytical tools in the biotech industry. The ARS can deliver a sample to any HPLC system that supports a simple digital interface. Dependent on the operation, the ARS can function as the master controller or as a slave to the HPLC.
Cell Counters:..	The ARS interfaces to industry-standard cell counters, such as Vi-Cell and Cedex, to ensure rapid delivery of samples as well as the recording and handling of the results.